ARRB1 Antilichaam - middengebied: FITC (ARP30523 P050-FITC)

Arrestin, beta 1

ARB1, ARR1

408

P49407

NP_004032

Human, Cow, Dog, Horse

The immunogen is a synthetic peptide directed towards the middle region of human ARRB1

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.

MAPK9; UBC; PTGER4; SRC; GNMT; NOTCH1; ARRDC1; PTAFR; MAP2K3; LIMK1; PDXP; MAPK14; CLTC; CFL1; AP2A1; MAP3K5; AKT1; AGTR1; MAP2K4; MAPK10; CSK; EDNRA; Agtr1a; NEK6; PIK3R2; NFKBIA; AXIN1; YY1; BTK; BAG1; ADRB1; ADH6; RPL15; PDE4D; Mlnr; Trhr; ARRDC4; ARRD

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 90%; Dog: 100%; Horse: 100%; Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Wet Ice

418

ARRB1

ARRB1

Rabbit

Beta-arrestin-1

NM_004041

NETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNN