Arrestine 1 (fosfo Ser412) Antilichaam

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

408

P49407

NP_004032.2

Human

Arrestin 1 (phospho Ser412) antibody was raised against a peptide sequence around phosphorylation site of Serine 412 (T-G-S (p) -P-Q) derived from Human Arrestin 1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

50 kDa

IgG

The antibody detects endogenous levels of Arrestin-1 only when phosphorylated at serine 412.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

ARRB1

Arrestin, beta 1

Homo sapiens

Greg Buchanan. AACR Meeting Abstracts, Apr 2006; 2006: 430.

D. Alex Groarke. Mol. Pharmacol., Feb 2001; 59: 375.

Karen McConalogue. Mol. Biol. Cell, Aug 1998; 9: 2305.

Maria Stella Lombardi. Stroke, Apr 2004; 35: 981 - 986.

ARR1, arrestin 2, arrestin beta 1, beta-arrestin-1

WB, IHC

10880136

Liquid