ART0380
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2267316-76-5
IACS-030380
ATM/ATR
PI3K/Akt/mTOR
C18H24N6O2S
ART0380 (IACS-030380) is a potent and selective, orally bioavailable inhibitor of ATR kinase, with an IC50 of 51.7 nM effectively inhibiting the enzyme activity of the ATR-ATRIP complex. It functions as an ATP-competitive inhibitor, binding to the ATP pocket of ATR, where ATP would typically bind. It interacts with the hinge through its morpholine oxygen and occupies the ribose pocket with a sulfoximine group. It also exhibits antitumor activity.
Beschrijving
ART0380 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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