ART5803
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis[1].
3058434-76-4
12352203
IGluR
Membrane Transporter/Ion Channel; Neuronal Signaling
COVID-19-immunoregulation
Inflammation/Immunology
[1]Kanno A, et al. Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis. Nat Commun. 2025 Jun 17;16 (1) :5292.
Room temperature
-80°C
http://file.medchemexpress.com/batch_PDF/HY-P991611/
Inhibitory Antibodies
No Development Reported
NMDA Receptor
Beschrijving
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) w
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