ArtritoMabTM Antibody Cocktail voor C57BL/6, TG

ArthritoMabTM Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely used collagen-induced arthritis (CIA) model. Many transgenic strains of mice are on a C57BL/6 background. However this strain is refractory to arthritis induction either by CIA or CAIA. Traditionally to overcome this in the CAIA model an increased dose of antibody cocktail is given. This reformulated cocktail of antibodies is optimized for production of arthritis in C57BL/6, inducing arthritis with lower doses of antibody. This new formulation can also be used in other strains of mouse, which traditionally require greater amounts of cocktail. The Collagen Antibody Induced Arthritis (CAIA) model is a relevant model for studying the efferent phase of RA, where leukocytes are attracted and respond to the immune complex in the joint. It is induced using a cocktail of antibodies to anti-CII and contains pathogenic features similar to that of RA such as pannus formation, cellular infiltration, synovitis and cartilage/bone destruction. Download the whitepaper. For use with Balb/c, DBA/1, R10.RIII strains, see ArthritoMabTM Antibody Cocktail for Balb/c, DBA/1, R10.RIII, 50 mg . Benefits of the CAIA model Length of study: Arthritis develops in mice typically within 24-48 hr allowing the completion of a study within 2 weeks reducing the number of assessments and scoring periods. Reduced group size: Rate of incidence is nearly 100% depending on the strain allowing for smaller group sizes. Synchronization: onset of disease is synchronized between animals simplifying treatment schedules. Steady & Controlled disease progression: No rapid & severe disease spikes enabling evaluation of all treatment schedules Susceptibility: Induce arthritis in transgenic strains with as little as 2 mg of Antibody. Comparison ArthritoMabTM Competitor Epitopes Recognized CB11, CB10, CB8 CB11 only Disease Progression Steady & Controlled Rapid & Severe Paw involvement Consistent & Predominantely rear Variable & unpredictable Amount required for C57Bl/6 2 mg (25 animals per vial) 5 mg (8 animals per vial) Abbreviations: Anti-Collagen Induced arthritis (ACIA) Monoclonal Antibody induced arthritis (mAb-RA) Collagen Antibody Induced Arthritis (CAIA)

ArthritoMabTM Antibody Cocktail is a reformulated cocktail of 4 monoclonal antibodies for the induction of arthritis as an alternative to the widely used collagen-induced arthritis (CIA) model. Many transgenic strains of...

ArthritoMabTM Antibody Cocktail for C57BL/6, TG, 50 mg

Antibodies