ARTS Antilichaam

ARTS Antibody: Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF-α and Fas ligand.

5414

O43236

AAG45673

Human

Unconjugated

Primary Antibodies

Apoptosis

ARTS Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

ARTS Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ARTS antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

32 kDa

IgG

SEPT4

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 1305 - Human Kidney Tissue Lysate

Cat. No. 10-101 - Human Lung Tissue Slide

Septin 4

Homo sapiens

Larisch S, Yi Y, Lotan R, Kerner H, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol 2000;2 (12) :915-21

Depraetere V. The ARTS of apoptosis. Nat Cell Biol. 2000;2 (12) :E219.

Paavola, P., Horelli-Kuitunen, N., Palotie, A. and Peltonen, L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics 1999;55 (1) :122-125

Zieger, B., Tran, H., Hainmann, I. , Wunderle, D., Zgaga-Griesz, A., Blaser, S. and Ware, J. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Gene 2000;261 (2) :197-203

ARTS Antibody: H5, ARTS, MART, SEP4, CE5B3, PNUTL2, hucep-7, BRADEION, hCDCREL-2, Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway

ELISA, WB, IHC-P, IF

12024871

Liquid