AS-8351
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM) . Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1
Unconjugated
Yellow solid
-20°C
Beschrijving
AS-8351 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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