ASC / TMS1 Antilichaam

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

29108

Q9ULZ3

Human, Mouse, Rat

Recombinant protein of human ASC / TMS1

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle

Affinity purification

HT-29

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 25kDa

IgG

PYCARD

BT-474

U-937

Mouse thymus

Mouse spleen

Rat spleen

PYD and CARD domain containing

Homo sapiens

ASC Antibody: ASC, TMS, TMS1, CARD5, TMS-1, ASC, Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, hASC

WB, IHC, IF, IP

Liquid