Asenapine onzuiverheid 1

Asenapine impurity 1 is an impurity of Asenapine. Asenapine, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder[1][2].

165890-26-6

12352005

H302, H315, H319, H335

Drug Intermediate

Others

Neurological Disease

95.0

O=C1[C@](C(C=C(Cl)C=C2)=C2OC3=C4C=CC=C3)([H])[C@]4([H])CN1C

C17H14ClNO2

299.76

H302, H315, H319, H335

[1]M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23 (1) :65-73. |[2]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl) . 2008 Feb;196 (3) :417-29.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-75405/Asenapine-impurity-1-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported