ASK1 (fosfo Ser966) Antilichaam

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

4217

Q99683

NP_005914.1

Human, Mouse

ASK1 (Phospho-Ser966) antibody was raised against a peptide sequence around phosphorylation site of serine 966 (S-I-S (p) -L-P) derived from Human ASK1.

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

155 kDa

This antibody detects endogenous level of ASK1 only when phosphorylated at serine 966.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

MAP3K5

Mitogen-activated protein kinase kinase kinase 5

Homo sapiens

Zhang W, et al. (2005) J Biol Chem. 280 (19) : 19036-19044. Fujii K, et al. (2004) Oncogene. 23 (29) : 5099-5104. Goldman EH, et al. (2004) J Biol Chem 2004 Mar 12; 279 (11) : 10442-10449. Zhang L, et al. (1999) Proc Natl Acad Sci U S A. 96 (15) : 8511-8515.

ASK1, MEKK5, MAPKKK5, SRK, ASK-1, M3K5, MAP3K5, MAPK/ERK kinase kinase 5

WB, IHC

5174547

Liquid