AT-1413
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acute myeloid leukemia (AML) cells. AT-1413 has antitumor activity in AML mouse models. AT-1413 can be used in Acute myeloid leukaemia, Breast cancer, Malignant melanoma and Myelodysplastic syndromes research. Recommended isotype control: Human IgG1 kappa, Isotype Control.
12352203
Transmembrane Glycoprotein
Immunology/Inflammation
Cancer-programmed cell death
Cancer
[AT-1413]
[1]De Jong G, et al. PS971 AT1413 ANTIBODY DERIVED FROM A CURED AML PATIENT RECOGNIZES A UNIQUE CD43 EPITOPE SHARED BY AML, MDS AND MELANOMA AND HAS IN VIVO ACTIVITY AS UNMODIFIED ANTIBODY AND AS BISPECIFIC T CELL ENGAGER[J]. HemaSphere, 2019, 3: 437-438.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991425/
Inhibitory Antibodies
No Development Reported
Beschrijving
AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acu
Specificaties
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