ATF-2 (fosfo Ser472) Antilichaam

Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.

1386

P15336

NP_001243019.1

Human, Mouse, Rat

ATF-2 (phospho Ser472) antibody was raised against a peptide sequence around phosphorylation site of Serine 472 (E-A-V (p) -A-T) derived from Human ATF-2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

54 kDa

IgG

The antibody detects endogenous levels of ATF-2 only when phosphorylated at serine 472.

ATF2

Activating transcription factor 2

Homo sapiens

Maekawa T., EMBO J. 8:2023-2028 (1989) .

Yang L., J. Immunol. 158:2522-2525 (1997) .

Kara C.J., Mol. Cell. Biol. 10:1347-1357 (1990) .

Activating 2, ATF2, cAMP response element binding protein CRE- BP1, CREB2, HB16

IHC

22538422

Liquid