ATF-4 (fosfo Ser219) Antilichaam

ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

468

P18848

NP_001666.2

Human, Mouse

ATF-4 (phospho Ser219) antibody was raised against a peptide sequence around phosphorylation site of Serine 219 (N-D-S (p) -G-T) derived from Human ATF-4.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

38 kDa

IgG

The Antibody detects endogenous levels of ATF-4 only when phosphorylated at Serine 219.

Western Blot: 1:500~1:1000

ATF4

Activating transcription factor 4

Homo sapiens

Sato T., Shimotohno K. J. Virol. 65:1420-1426 (1991)

Leiden J.M. Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824 (1992)

Bridgeman A.M. Wright H. Nature 402:489-495 (1999)

ATF4, CREB-2, DNA-binding protein TAXREB67, TXREB

WB

33469976

Liquid