ATF-antilichaam - N-terminalgebied: FITC (ARP38957_T100-FITC)

Apoptosis antagonizing transcription factor

DED, BFR2, CHE1, CHE-1

26574

Q9NY61

NP_036270

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human AATF

The AATF is a protein that was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. AATF contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of AATF interfered with MAP3K12 induced apoptosis.The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

MDM2; DAPK3; AR; HIPK2; NGDN; UBC; TSG101; LIN28A; MMS19; ZNF468; NEDD4L; WHSC1; SMAD3; EFNB3; CPD; UBD; CAND1; PIN1; SIRT7; SUMO2; CHEK2; RELA; tat; MAGED1; PCBD2; SS18L1; LZTR1; MPHOSPH6; POLR2J; MPP6; PAWR; DAZAP2; ATR; ATM; CHEK1; LDOC1; SP1; RB1; MAP

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

AATF is supported by BioGPS gene expression data to be expressed in Daudi

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

63kDa

Lehner, B. (2004) Genome Res. 14 (7), 1315-1323

Wet Ice

560

AATF

AATF

Rabbit

Protein AATF

NM_012138

MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDF