ATF2 (fosfo Thr69 / 51) Antilichaam

Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.

1386

P15336

NP_001871.2

Human, Mouse, Rat

ATF2 (Phospho-Thr69 or 51) antibody was raised against a peptide sequence around phosphorylation site of threonine 69 or 51 (D-Q-T (p) -P-T) derived from Human ATF2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

65 - 75 kDa

This antibody detects endogenous level of ATF-2 only when phosphorylated at threonine 69 or 51.

Western Blot: 1:500, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

ATF2

Activating transcription factor 2

Homo sapiens

Sevilla A, et al. (2004) J Biol Chem. 279 (26) : 27458-27465. Alsayed Y, et al. (2001) J Biol Chem. 276 (6) : 4012-4019. Abdel-Hafiz H A, et al. (1992) Mol Endocrinol. 6: 2079-2089. Gupta S, et al. (1995) Science. 267: 389-393.

HB16, CREB2, TREB7, CREB-2, CRE-BP1, PKB, RAC, CREBP1

WB, IHC, IF

22538422

Liquid