ATF3 Antilichaam - middengebied: Biotine (ARP36556_P050-Biotine)

Activating transcription factor 3

467

P18847

NP_001665

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human ATF3

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF3 represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

SUV39H1; BATF3; MAFF; CREB3; FOSL1; MAFG; JUNB; JUN; FOS; DDIT3; DBP; ATF2; CEBPG; CEBPE; CEBPA; ATF4; ATF3; BATF; HSP90AA1; SRA1; ZNF212; ID3; FHL2; SUMO1; SUMO3; HDAC10; HDAC5; HDAC6; HDAC4; HDAC3; HDAC1; SMARCA4; PDX1; ACTB; UBC; SUMO2; STAT1; MDM2; SM

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 93%; Yeast: 75%; Zebrafish: 80%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

20kDa

Sampson, M.J., (2008) Eur. J. Endocrinol. 158 (5), 729-739

Wet Ice

181

ATF3

ATF3

Rabbit

Cyclic AMP-dependent transcription factor ATF-3

NM_001674

PLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK