ATG4B Antilichaam

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) . ATG4B, also known as AUTL1, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3) . ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4) . ATG4B has been found to be a novel protective protein in inflammatory colitis (5) .

23192

Q9Y4P1

NP_037457

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

ATG4B antibody is affinity chromatography purified via peptide column.

Cat. No. 1225 - Ramos Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Chicken: (88%)

ATG4B antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ATG4B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ATG4B antibody is human, mouse and rat reactive. At least two isoforms of ATG4B are known to exist; this antibody will detect only the larger isoform. ATG4B is predicted to not cross-react with other ATG4 proteins.

ATG4B

Cat. No. 1205 - Jurkat Cell Lysate

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 10-901 - Human Spleen Tissue Slide

Autophagy related 4B, cysteine peptidase

Homo sapiens

Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-906.

Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.

Marino G, Uria JA, Puente XS, et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J. Biol. Chem. 2003; 278:3671-8.

Li M, Hou Y, Wang J, et al. Kinetic comparisons of mammalian Atg4 homologues indicate selective preferences towards diverse Atg8 substrates. J. Biol. Chem. 2011; 286:7327-38.

Autophagy related 4B cysteine peptidase, APG4B, APG4-B, AUTL1

ELISA, WB, IHC-P, IF

47132611

Liquid