ATG4C Antilichaam

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) . ATG4C, also known as autophagin-3, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3) . Recent studies have shown that ATG4C and Beclin-1 are regulated by the microRNA miR-376b; overexpression of miR-376b led to decreased mRNA and protein levels, thereby blocking starvation and TOR inhibition-related autophagy (4) .

84938

Q96DT6

NP_835739

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

ATG4C antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 - A549 Cell Lysate

1 mg/mL

ATG4C antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ATG4C antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ATG4C antibody is human, mouse and rat reactive. ATG4C is predicted to not cross-react with other ATG4 proteins.

ATG4C

Cat. No. 10-101 - Human Lung Tissue Slide

Autophagy related 4C, cysteine peptidase

Homo sapiens

Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-906.

Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.

Marino G, Uria JA, Puente XS, et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J. Biol. Chem. 2003; 278:3671-8.

Korkmaz G, le Sage C, Tekirdag KA, et al. miR-376b controls starvation and TOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012; 8:165-76.

ATG4C Antibody: APG4C, AUTL1, AUTL3, APG4-C, APG4C, Cysteine protease ATG4C, AUT-like 3 cysteine endopeptidase

ELISA, WB, IHC-P, IF

30410846

Liquid