ATG9A Antilichaam

ATG9A Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG9A, a multi-spanning membrane protein localizing to the Golgi apparatus and late endosomes, has been proposed to mediate membrane transport to generate autophagosomes. ATG9A has also been implicated as a regulator of STING (stimulator of interferon genes) -mediated innate immune response.

79065

Q7Z3C6

NP_076990

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

ATG9A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1401 - Mouse Heart Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

ATG9A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ATG9A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ATG9A

Cat. No. 10-501 - Human Heart Tissue Slide

ATG9 autophagy related 9 homolog A (S. cerevisiae)

Homo sapiens

Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene2004; 23:2891-906.

Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis1993; 14:2501-5.

Kamada Y, Funakoshi T, Shintani T, et al. Tor-mediated induction of autophagy via Apg1 protein kinase complex. J. Cell. Biol.2000; 150:1507-13.

Webber JL, Young AR, and Tooze SA. Atg9 trafficking in mammalian cells. Autophagy2007; 3:54-6.

ATG9A Antibody: mATG9, APG9L1, MGD3208, Autophagy-related protein 9A, APG9-like 1

ELISA, WB, IHC-P, IF

116089287

Liquid