ATM (Ab 1981) Antilichaam

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

472

Q13315

NP_000042.3

Human, Mouse

ATM (Ab-1981) antibody was raised against a peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

350 kDa

This antibody detects endogenous level of total ATM protein.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

ATM

Ataxia telangiectasia mutated

Homo sapiens

Gupta A. et al. (2005) Mol Cell Biol. 25 (12) : 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4 (6) : 249-252. Silverman J. et al. (2004) Genes Dev. 18 (17) : 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31 (6) : 1715-1724.

AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, C1orf215, LAP18, OP18, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM

WB, IF

71902540

Liquid