ATM Antilichaam

ATM Antibody: DNA double strand breaks represent a major threat to an organism's genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.

472

Q13315

AAB65827

Human

Unconjugated

Primary Antibodies

Homeostasis, Cancer

ATM Antibody is affinity chromatography purified via peptide column.

Cat. No. 1224 - Daudi Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (86%), Mouse: (71%)

ATM Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ATM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ATM

Cat. No. 1369 - Human Lymph node Tissue Lysate

Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

Ataxia telangiectasia mutated

Homo sapiens

Cahill D, Connor B, and Carney JP. Mechanisms of eukaryotic DNA double strand break repair. Front. Biosci. 2006 ; 11 :1958-76.

Dasika GK, Lis SC, Zhao S, et al. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 1999; 18:7883-99.

ATM Antibody: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated

ELISA, WB, IHC-P, IF

2304971

Liquid