ATMIN Antilichaam

The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1) . ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2) . It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3) .

23300

O43313

NP_056066

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

ATMIN antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

ATMIN Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ATMIN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ATMIN antibody is human, mouse and rat reactive. At least three isoforms of ATMIN are known to exist.

ATMIN

Cat. No. 17-002 - A-431 Cell Slide

ATM interactor

Homo sapiens

McNees CJ, Conlan LA, Tenis N, et al. ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. EMBO J. 2005; 24:2447-57.

Jurado S, Smyth I, van Denderen B, et al. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet. 2010; 6:e1001170.

Jurado S, Conlan LA, Baker EK, et al. ATM substrate Chk2-interating Zn2+ finger (ASCIZ) is a bi-functional transcriptional activator and feedback sensor in the regulation of Dynein Light Chain (DYNLL1) expression. J. Biol. Chem. 2012; 287:3156-64.

ATMIN Antibody: ASCIZ, ZNF822, KIAA0431, ATM interactor, Zinc finger protein 822, ASCIZ

ELISA, WB, ICC, IF

54792092

Liquid