ATP-citraatlyase (ACLY) Mouse Monoclonal Antibody [Kloon ID: LBI3G8]

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Carrier-free (BSA/glycerol-free) ACLY mouse monoclonal antibody, clone LBI3G8

ACL; ATPCL; CLATP

Homo sapiens ATP citrate lyase (ACLY), transcript variant 1, mRNA.

47

P53396

Unconjugated

Citrate cycle (TCA cycle), Metabolic pathways

Citrate cycle (TCA cycle), Metabolic pathways

WB 1:2000, IHC 1:50, IF 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

ACLY

https://www.ncbi.nlm.nih.gov/gene/?term=47

https://www.uniprot.org/uniprot/P53396