ATP dinatriumzout, 100mM oplossing, PCR graad

ATP (Adenosine 5'-triphosphate) disodium salt, 100mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice[1][2][3][4].

987-65-5

Adenosine 5'-triphosphate disodium salt, 100mM Solution, PCR Grade

12352200

Bacterial; Endogenous Metabolite; Interleukin Related; NOD-like Receptor (NLR)

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Metabolism-protein/nucleotide metabolism

Infection; Inflammation/Immunology; Metabolic Disease

0

O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O

C10H14N5Na2O13P3

551.14

[1]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35 (3) :852-8.|[2]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112 (2) :358-404.|[3]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[4]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8 (5) : e63759.

Blue Ice

Solution, -20°C, 2 years

http://file.medchemexpress.com/batch_PDF/HY-B2176I/ATP-disodium-salt-100mM-Solution-PCR-Grade-SDS-MedChemExpress.pdf

Biochemical Assay Reagents

No Development Reported

IL-1; NLRP3