ATP1B1 Antilichaam - middengebied: HRP (ARP44411 P050-HRP)

ATPase, Na+/K+ transporting, beta 1 polypeptide

ATP1B

481

P05026

NP_001001787

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human ATP1B1

ATP1B1 belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit.The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.

Bace1; EGFR; ATP4A; UBC; BRCA1; BARD1; PAXIP1; GCH1; USP4; NEDD4L; ELAVL1; NDRG2; TRMT2A; DDAH2; HLA-DRB1; HLA-DRA; EZH2; CRIP2; KMT2B; PSME1; HLA-DRB5; HLA-DRB4; HLA-DRB3; LRIF1; FXYD7; FXYD1

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

ATP1B1 is strongly supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 92%; Dog: 86%; Guinea Pig: 85%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 92%; Rat: 100%; Sheep: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

35kDa

Vagin, O., (2005) J. Biol. Chem. 280 (52), 43159-43167

Wet Ice

301

ATP1B1

ATP1B1

Rabbit

Sodium/potassium-transporting ATPase subunit beta-1

NM_001001787

VMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLL

Beta-1