ATP2A2 Antilichaam - C-terminaal gebied: Biotine (ARP45159_P050-Biotine)

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

DD, DAR, ATP2B, SERCA2

488

P16615

NP_733765

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human ATP2A2

ATP2A2 is one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in two transcript variants encoding different isoforms.

ERLIN2; UBC; SUMO2; SPRTN; PTPLAD1; LGR4; MDM2; ASB14; ASB5; ASB17; ASB1; TRIM13; SUZ12; RNF2; EZH2; rev; S100A1; EGFR; ADRB2; ILK; CLN5; CLN3; env; NOS2; ATF2; CFTR; MDC1; ECT2; SLC3A2; ITPR3; CUL3; FBXO25; SPP1; SIRT7; ELAVL1; SUMO1; AMFR; HDAC5; CAMK2A

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

115kDa

Korosec, B., (2008) Cancer Genet. Cytogenet. 181 (2), 112-118

Wet Ice

1042

ATP2A2

ATP2A2

Rabbit

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

NM_170665

VNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYV