ATP7B Antilichaam - middengebied: Biotine (ARP44524_P050-Biotine)

ATPase copper transporting beta

WD, PWD, WC1, WND

540

P35670

NP_000044.2

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human ATP7B

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD) .

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 82%; Guinea Pig: 82%; Horse: 82%; Human: 100%; Mouse: 91%; Rabbit: 92%; Rat: 91%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

74kDa

Wet Ice

676

ATP7B

ATP7B

Rabbit

Copper-transporting ATPase 2

NM_000053.3

IIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITV