ATR Antilichaam

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

545

Q13535

Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human ATR (NP_001175.2) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Signal Transduction

Affinity purification

Mouse lung

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 316kDa

IgG

WB: 1:500 - 1:2000

ATR

Ataxia telangiectasia and Rad3 related

Homo sapiens

ATR, FRAP-related protein-1, FCTCS, SCKL1, MEC1, Protein kinase ATR, Rad3 related protein, SCKL, FRAP-related protein 1, FRP1

WB

Liquid