AURKB Antilichaam (13E8D3]

AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein (about 39 kDa), localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis.It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases

9212

Q96GD4

Q96GD4

Human

Ni-NTA purified truncated recombinant AURKB expressed in E. Coli strain BL21 (DE3) .

13E8D3

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

AURKB monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Isotype: IgG1

AURKB

Aurora kinase B

Homo sapiens

Song J et al. Immunity 22:621-31 (2005) .

Kapoor P et al. Mol Cell Biol 25:4934-45 (2005) .

AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5, Aurora 1, AIM-1, AIK2, AurB, IPL1, PPP1R48, aurkb-sv1, aurkb-sv2

ELISA, WB

317373473