AVLX-144

AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95) . AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease[1].

1413933-25-1

12352209

IGluR

Membrane Transporter/Ion Channel; Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

CC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC(CCOCCOCCN(CCOCCOCCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

C126H221N43O41

2994.37

[1]Wu B, et al. A spatiotemporal atlas of cholestatic injury and repair in mice. Nat Genet. 2024 May;56 (5) :938-952.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11263/

Peptides

No Development Reported