AX-024
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AX-024 is a potent (IC50 ~ 1 nM) and specific inhibitor of T cell antigen receptor (TCR) -dependent T cell activation. It inhibited neither B cell proliferation triggered by B cell antigen receptor (BCR), TLR4, CD40 agonists nor IL-2-dependent proliferation of T lymphoblasts. AX-024 binds to the SH3.1 domain of the adaptor protein Nck blocking its interaction with the CD3 subunit on the T cell antigen receptor. AX-024 displayed protective effects in mouse models of psoriasis, allergic asthma, and multiple sclerosis. Importantly, the therapeutic effect of AX-024 persisted after removal of the drug in contrast to fingolimod suggesting a persistent modification of autoimmune T cells. Currently in clinical trials.
Unconjugated
White solid
-20°C
Beschrijving
AX-024 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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