AZD1208
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1; 150 nM PIM2; 9 nM PIM3) .1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.
Unconjugated
Yellow solid
-20°C
Beschrijving
AZD1208 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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