B2M-antilichaam

B2M Antibody: Beta2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2) . B2M is involved in the presentation of peptide antigens to the immune system and plays a critically important role in immune system function (3) . It is expressed on nearly all nucleated cells and contains one Ig-like C1-type (immunoglobulin-like) domain (2,3) . Mutations in the Beta 2-microglobulin gene can enhance the progression of malignant melanoma and osteoarthropathy (4,5) .

567

P61769

NP_004039

Human

Unconjugated

Primary Antibodies

Immunology

B2M Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (83%), Rat: (83%)

B2M Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

B2M antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

B2M antibody is human reactive.

B2M

Beta-2-microglobulin

Homo sapiens

Krangel MS, Orr HT, and Strominger JL. Assembly and maturation of HLA-A and HLA-B antigens in vivo. Cell 1979; 18:979-91.

Skjodt K, Welinder KG, Crone M, et al. Isolation and characterization of chicken and turkey beta 2-microglobulin. Mol. Immunol. 1986; 23:1301-9.

Ohashi K. Pathogenesis of beta2-microglobulin amyloidosis. Pathol. Int. 2001; 51:1-10.

Blum C, Graham A, Yousefzadeh M, et al. The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer. Int. J. Oncol. 2008; 33:579-84.

B2M Antibody: Beta-2-microglobulin

ELISA, WB, IHC-P, IF

4757826

Liquid