B7H3 Antilichaam [4H3]

CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1) . CD276 mRNA is widely expressed, but its protein expression is usually rather low (2) . CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3) . In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4) . It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.

80381

Q5ZPR3

NP_001019907

Human

B7-H3 antibody was raised against the extracellular domain of human B7-H3

4H3

Unconjugated

Primary Antibodies

Immunology

B7-H3 Antibody is supplied as protein A purified IgG1.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

B7-H3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

None

Blue Ice

B7-H3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1, k

CD276

Cat. No. 17-010 - HEK293 Cell Slide

CD276

Homo sapiens

Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.

Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.

Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.

Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71.

B7-H3 Antibody: CD276 molecule, B7H3, B7RP-2, 4Ig-B7-H3, CD276

ELISA, WB, IHC-P, ICC, IF, Flow

67188443

Liquid