BAB2 (IN) Antilichaam

AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type) . AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro) viral) cytosolic DNA, thus contributing to the onset of apoptosis

84883

Q9BRQ8

Q9BRQ8

Human, Mouse, Rat

9655

Unconjugated

Primary Antibodies

Signal Transduction

AIFM2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 – HeLa Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Gorilla (100%) ; chimpanzee (100%), cow (100%), Horse (93%)

AIFM2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AIMF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

WB: 2 μ g/mL; IHC: 1 μ g/mL; IF: 20 μ g/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunofluorescence in human samples and Immunohistochemistry in human, mouse and rat samples. All other applications and species not yet tested.

Human AIFM2 has 2 isoforms, including isoform 1 (373aa, 40.5kD) and isoform 2 (336aa, 36.5kD) . Mouse AIFM2 has 2 isoforms, isoform 1 (373aa, 40.6kD) and isoform 2 (380aa, 41.4kD) . Rat AIFM2 has one isoform (373aa, 40.7kD) . 9653 can detect AIFM2 in human, mouse and rat.

AIMF2

Cat. No. 17-001 – HeLa Cell Slide

Apoptosis inducing factor mitochondria associated

Homo sapiens

Dai et al. Biochem Biophys Res Commun. 2020; 523 (4) :966-971

Bersuker et al. Nature 2019; 575 (7784) :688-692

Doll et al. Nature 2019; 575 (7784) :693-698

Chen et al. J Mol Neurosci 2019; 68 (2) : 304-310

Gong et al. J Biol Chem 2007; 282 (41) :30331-30340

AIMF2

ELISA, IHC, WB, IF

74752283

Liquid