BAB2 (IN) Peptide

AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type) . AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro) viral) cytosolic DNA, thus contributing to the onset of apoptosis

84883

Q9BRQ8

Q9BRQ8

Peptides

200 ug/mL

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Blue Ice

Store AIFM2 (IN) Peptide at -20˚ C, stable for one year.

AIFM2 (IN) Peptideis used for blocking the activity of theAIFM2 (IN) Antibody

Apoptosis inducing factor mitochondria associated

Homo sapiens

Dai et al. Biochem Biophys Res Commun. 2020; 523 (4) :966-971

Bersuker et al. Nature 2019; 575 (7784) :688-692

Doll et al. Nature 2019; 575 (7784) :693-698

Chen et al. J Mol Neurosci 2019; 68 (2) : 304-310

Gong et al. J Biol Chem 2007; 282 (41) :30331-30340

AIMF2

Blocking

Human

74752283

Liquid