Bac7 (1-35) (acetaat)

Bac7 (1-35) acetate is a proline-rich antimicrobial peptide. Bac7 (1-35) acetate efficiently binds to different regions of prokaryote ribosomes, leading to the inhibition of protein synthesis. Bac7 (1-35) acetate demonstrates in vitro activity against P. aeruginosa strains[1].

12352209

Bacterial

Anti-infection

Infection

98.88

O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N2[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N4[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N7[C@H](C(N[C@H](C(N8[C@H](C(N[C@H](C(N9[C@H](C(N[C@H](C(N%10[C@H](C(NCC(N%11[C@H](C(N[C@H](C(N%12[C@H](C(N[C@H](C(N%13[C@H](C(N[C@H](C(N%14[C@H](C(N[C@H](C(N%15[C@H](C(N[C@H](C(N%16[C@H](C(O)=O)CCC%16)=O)CC%17=CC=CC=C%17)=O)CCC%15)=O)CC(C)C)=O)CCC%14)=O)CCCNC(N)=N)=O)CCC%13)=O)[C@H](CC)C)=O)CCC%12)=O)CCCNC(N)=N)=O)CCC%11)=O)=O)CCC%10)=O)CCCNC(N)=N)=O)CCC9)=O)CC%18=CC=CC=C%18)=O)CCC8)=O)CC(C)C)=O)CCC7)=O)CCCNC(N)=N)=O)CCC6)=O)CCCNC(N)=N)=O)CCC5)=O)CCCNC(N)=N)=O)CCC4)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC3)=O)CCC2)=O)CCCNC(N)=N)=O)CCC1)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CCCNC(N)=N.CC(O)=O.[x]

C196H322N68O36·xC2H4O2

4207.09 (free base)

[1]Runti G, et al. The Mechanism of Killing by the Proline-Rich Peptide Bac7 (1-35) against Clinical Strains of Pseudomonas aeruginosa Differs from That against Other Gram-Negative Bacteria. Antimicrob Agents Chemother. 2017 Mar 24;61 (4) :e01660-16.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5731A/Bac7-1-35-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported