BACE2 Antilichaam

BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) . BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

25825

Q9Y5Z0

AAF17078

Human

Unconjugated

Primary Antibodies

Neuroscience

BACE2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)

BACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

BACE2

Cat. No. 1461 - Rat Heart Tissue Lysate

Beta-site APP-cleaving enzyme 2

Homo sapiens

Vassar R, et al. β -secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999;286:735-41

Hussain I, et al. Identification of a novel aspartic protease (Asp 2) as β -secretase. Mol Cell Neurosci 1999;14:419-27

Sinha S, et al. Purification and cloning of amyloid precursor protein β -secretase from human brain. Nature 1999;402:537-40

Yan R, et al. Membrane-anchored aspartyl protease with Alzheimer's disease β -secretase activity. Nature 1999;402:533-7

BACE2 Antibody: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, UNQ418/PRO852, Beta-secretase 2, Aspartic-like protease 56 kDa, ASP1

ELISA, WB, IHC-P

6561812

Liquid