BACH2 Antilichaam / BTB en CNC homologie 2

Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Implicated in immunodeficiency 60. Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE) . Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation.

Flow cytometry: 1-2ug/million cells

Q9BYV9

Human

A portion of amino acids 11-132 from human BACH2 protein was used as the immunogen for the BACH2 antibody.

PCRP-BACH2-5B11

FACS

Protein G affinity

Purified

This BACH2 antibody is available for research use only.

Aliquot the BACH2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the BACH2 antibody should be determined by the researcher.

Nucleus

Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using BACH2 antibody (clone PCRP-BACH2-5B11) . These results demonstrate the foremost specificity of the PCRP-BACH2-5B11 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.