BAD (fosfo Ser91/128) Antilichaam

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

572

Q92934

NP_004313.1

Human, Mouse, Rat

BAD (phospho Ser91/128) antibody was raised against a peptide sequence around phosphorylation site of Serine 91 (E-P-S (p) -P-F) derived from Human BAD or Serine 128 (E-P-S (p) -P-F) derived from Mouse BAD.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

22 kDa

IgG

The antibody detects endogenous levels of BAD only when phosphorylated at serine 91/ serine 128.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

BAD

BCL2-associated agonist of cell death

Homo sapiens

Wang H.-G., Cell 87:629-638 (1996) .

Ottilie S., J. Biol. Chem. 272:30866-30872 (1997) .

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

BAD, BBC6, BCL2L8, Bcl- XL/Bcl-2 associated death promoter

WB, IHC

10835069

Liquid