BAFF Antilichaam

BAFF Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κ B and c-jun N-terminal Kinase) . BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.

10673

Q9Y275

NP_006564

Human, Mouse, Rat

2221

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 3) : Anti-BAFF antibodies (2221) detected human BAFF recombinant protein at different concentrations. Recombinant Protein Test2221 Regulated expression validation (Figure 6-8) : BAFF expression detected by anit-BAFF antibodies (2221) was up-regulated in patients with myloma or Graves’ disease or in murine transplanted heart. Regulated expression validation2221

Chemokines & Cytokines, Cancer

BAFF Antibody is Ion exchange chromatography purified.

Cat. No. 1209 - HL60 Cell Lysate

1 mg/mL

BAFF Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BAFF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human BAFF has 3 isoforms, including isoform 1 (285aa, 31kD), isoform 2 (266aa, 29kD) and isoform 3 (164aa, 17.6kD) . Mouse BAFF has 2 isoforms, including isoform 1 (309aa, 34kD) and isoform 2 (290aa, 32kD) . Rat BAFF has only one isoform (274aa, 30kD) . 2221 can detect two longer human isoforms, mouse and rat.

TNFSF13B

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Cat. No. 17-009 - HL-60 Cell Slide

Tumor necrosis factor (ligand) superfamily, member 13b

Homo sapiens

Moore et al. Science 1999;285:260-3.

Schneider et al. J Exp Med 1999;189:1747-56.

Shu et al. J Leukoc Biol 1999;65:680-3.

Mukhopadhyay et al. J Biol Chem 1999 ;274:15978-81.

16818641

26214745

15368291

12867412

BAFF Antibody: DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, UNQ401/PRO738, Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator

ELISA, WB, ICC, IF, IHC

5730097

Liquid