BAFF-ontvanger, oplosbaar

BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) . BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.

TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

115650

Q96RJ3

NP_443177

NM_052945

22q13.1-q13.31

Human

Mouse

MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

< 0.1 ng/µg of protein (< 1EU/µg)

> 95% by SDS-PAGE & HPLC analyses

Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF.

76

Lyophilized

7.7 kDa

E. coli