BAMBI Antilichaam

BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1) . BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3) . BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4) . BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5) .

25805

Q13145

NP_036474

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Stem Cell

BAMBI antibody is affinity chromatography purified via peptide column.

Cat. No. 1402 - Mouse Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Sheep: (88%)

BAMBI antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BAMBI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

BAMBI antibody is human, mouse and rat reactive.

BAMBI

Cat. No. 10-101 - Human Lung Tissue Slide

BMP and activin membrane-bound inhibitor

Homo sapiens

Onichtchouk D, Chen YG, Dosch R, et al. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999; 401:480-5.

Yan X, Lin Z, Chen F, et al. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol. Chem. 2009; 284:30097-104.

Grotewold L, Plum M, Dildrop R, et al. Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech. Dev. 2001; 100:327-30.

Fritzmann J, Morkel M, Besser D, et al. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 2009; 137:165-75.

BMP and activin membrane-bound inhibitor homolog

ELISA, WB, IHC-P, IF

6912534

Liquid