BANF1 Antilichaam

BANF1 Antibody: Barrier-to-autointegration factor 1 (BANF1) is a conserved chromatin protein that non-specifically binds double-stranded DNA. BANF1 also interacts with a family of nuclear proteins that include LAP2, emerin, and MAN1. It is also a host cell component of retroviral pre-integration complexes (PICs), including that of HIV. BANF1 will bind to p55 Gag (the structural precursor of HIV-1 virions) as well as its cleaved product matrix. In addition to being a host cell component of the PIC, it is thought that BANF1 is also present at low levels in incoming virions, and thus might contribute to the assembly or activity of HIV-1 PICs through direct binding to matrix as well as DNA.

8815

O75531

AAH05942

Human

4017

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 1) shows similar BANF1 expression profile in human and mouse cell lines detected by two independent anti-BANF1 antibodies that recognize different epitopes, 4017 against C-terminus domain and 4019 against N-terminus domain. BANF1 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4017 4019

Infectious Disease

BANF1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (100%), Rat: (100%)

BANF1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BANF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human BANF1 has one isoform (89aa, 10kD) . Mouse BANF1 has one isoform (89aa, 10kD) and Rat BANF1 also has one isoform (89aa, 10kD) . 4017 can detect human, mouse and rat.

BANF1

Cat. No. 10-401 - Human Kidney Tissue Slide

Barrier to autointegration factor 1

Homo sapiens

Furukawa. J. Cell Sci. 1999; 112:2485-92.

Cai et al. EMBO J. 2001; 20:4399-407.

Chen and Engelman. Proc. Natl. Acad. Sci. USA 1998; 95:15270-4.

BANF1 Antibody: BAF, NGPS, BCRP1, D14S1460, BAF, BCRG1, Barrier-to-autointegration factor, Breakpoint cluster region protein 1

ELISA, WB, IF

13543577

Liquid