BAP31 Antilichaam

BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. Bap31 may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopically, is also a potent inducer cell death.

10134

P51572

NP_005736

Human, Mouse, Rat

3675

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar BAP31 expression profile in human cell lines detected by two independent anti-BAP31 antibodies that recognize different epitopes, 3675 against central domain and 64-237, against recombinant protein. BAP31 proteins are detected in all tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3675 64-237

Signal Transduction

BAP31 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1462 - Rat Lung Tissue Lysate

1 mg/mL

BAP31 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BAP31 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human BAP31 has 2 isoforms, including isoform 1 (246aa, 28kD) and isoform 2 (313aa, 35kD) . Mouse BAP31 has one isoform (245aa, 28kD) and Rat BAP31 also has one isoform (245aa, 28kD) . 3675 can detect human, mouse and rat.

BCAP31

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 1223 - Caco-2 Cell Lysate

Cat. No. 1282 - 3T3/NIH Cell Lysate

B-cell receptor-associated protein 31

Homo sapiens

Ng et al. J. Cell Biol.1997; 139:327-38.

Kim et al. EMBO J.1994; 13:3793-800.

Zen et al. J. Biol. Chem.2004; 279:44924-30.

BAP31 Antibody: CDM, DDCH, BAP31, 6C6-AG, DXS1357E, B-cell receptor-associated protein 31, 6C6-AG tumor-associated antigen, BCR-associated protein 31

ELISA, WB, IHC-P

32171186

Liquid