BAX Antilichaam

Apoptosis is a highly regulated process that is essential for the development and maintenance of multicellular organisms. The BAX protein is a crucial regulator of apoptosis, promoting cell death by permeabilizing the mitochondrial outer membrane and initiating the release of cytochrome c, which triggers a cascade of events leading to cell death. With its ability to induce apoptosis, the BAX protein acts as a safeguard against abnormal cell growth and development, ultimately ensuring cellular homeostasis. The activity of the BAX protein is tightly regulated by a variety of factors, including interactions with other proteins, post-translational modifications, and subcellular localization. Dysregulation of BAX activity can have serious consequences, leading to various diseases such as cancer, neurodegenerative disorders, and autoimmune diseases.

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100, Immunofluorescence: 1-50-1:100

Q07812

Human

A portion of amino acids 51-79 from the human protein was used as the immunogen for the BAX antibody.

WB, IHC-P, IF

Antigen affinity

Antigen affinity purified

This BAX antibody is available for research use only.

Store the BAX antibody at -20°C.

In 1X PBS, pH 7.4, with 0.09% sodium azide and 50% glycerol

Titration of the BAX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Cytoplasm, Nucleus

Western blot testing of human 1) 293 and 2) HT-1080 cell lysate with BAX antibody. Predicted molecular weight ~21 kDa.