Bax-antilichaam [6A7]

Bax is a 20-22 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. In murine thymocytes, it is expressed primarily as a cytoplasmic protein. Over-expression of Bax promotes apoptosis by formation of homodimers and through heterodimerization with Bcl-2, an inhibitor of apoptosis. The monoclonal antibody 6A7 reacts with human, mouse and rat Bax but does not bind the soluble cytosolic form of Bax; however, treatment of cells with non-ionic detergents exposes the epitope and allows binding of 6A7 to monomeric forms of Bax but not Bax complexed with either Bcl-2 or Bcl-xL.

581;12028;24887

Q07812

Q07812

Human, Mouse, Rat, Monkey, Bovine

Bax peptide (a.a. 12-24) common to mouse, rat, and human

[6A7]

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Obesity

0.1 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG1

Bax

Bax Antibody [6A7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and neutralization assays.

BAX

BCL2 associated X, apoptosis regulator

Homo sapiens

Apoptosis regulator BAX, BCL2 associated X protein

Flow

Liquid