BAX Antilichaam, KO gevalideerd

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

581

Q07812

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human BAX (NP_620116.1) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction

Affinity purification

MCF-7

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 23kDa

IgG

BAX

HT-1080

BCL2-associated X protein

Homo sapiens

Bax Antibody: BCL2L4, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4

WB, IF

Liquid