BC-LI-0186
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
695207-56-8
DNA/RNA Synthesis
Cell Cycle
CC (C) C1=C (C) N (C) N (C1=O) C2=CC=C (C=C2) [S] (=O) (=O) NCCOC3=CC=CC=C3
C22H27N3O4S
BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.
3 years -20°C powder
Beschrijving
BC-LI-0186 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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