BCAM Antilichaam

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu (a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.

4059

P50895

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 352-547 of human BCAM (NP_005572.2) .

Unconjugated

Primary Antibodies

Immunology

Affinity purification

U-251MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 100kDa

IgG

BCAM

HepG2

Basal cell adhesion molecule (Lutheran blood group)

Homo sapiens

AU, CD239, LU, MSK19, basal cell adhesion molecule, Auberger b antigen, B-CAM cell surface glycoprotein, B-cell adhesion molecule, F8/G253 antigen, Lutheran blood group variant LUGA, basal cell adhesion molecule (Lu and Au blood groups)

WB, IHC

Liquid